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ASK1ing for trouble How could mutant SOD1 downregulate SLACK?The researchers suspected that these effects may be triggered by ASK1, a key kinase that has been previously implicated in the destruction of motor neurons in the disease (Raoul et al., 2002).To mark the 10th anniversary of this landmark discovery, Cell Press is pleased to announce a symposium focused on i PSC research and applications.We are excited to bring together leaders in biology, medicine, and industry to give an up-to-date view of this exciting and rapidly moving area.What’s more, SOD1 G85R oligomers increased excitability of these neurons.Injection of these soluble 300 k Da protein complexes decreased the neuron’s resting membrane potential and increased its susceptibility to firing in response to applied stimuli, they found.At this meeting, you can expect to hear about the latest advances in technology development, mechanistic understanding, and therapeutic application of reprogramming for both drug development and cell-based therapy.

They found that SOD1 or mutant SOD1 G85R monomers had no effect.Increased activity in the motor cortex of the brain may occur in most forms of ALS (see September 2015 news).But whether this hyperexcitability contributes to the disease remains an open question.Now, researchers at Yale University make the case that ALS-linked mutant SOD1 may downregulate a key sodium-gated potassium ion channel, known as SLACK, through an apoptosis signal-regulating kinase 1 (ASK1)-based mechanism (Zhang et al., 2017).The findings may help explain how motor neuron hyperexcitability occurs in ALS.

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